NEW HAVEN, Conn. -- The search for a missing Yale graduate student who was set to get married this weekend intensified on Wednesday.

Yale University police said Annie Le, a graduate student at the Yale School of Medicine, has been missing since Tuesday morning.

Police said they believe Le left the Sterling Hall of Medicine where she had an office before 10 a.m. They said there are records of her swiping her card to get into a lab, where she was captured by the building's surveillance cameras. They said she hasn't been seen or heard from since.

University police said Le's purse, containing her cell phone, credit cards and money, was left in the laboratory on Amistad Street.

Le is described as being 4 feet 11 inches tall, and weighing about 90 pounds. She has shoulder-length brown hair and brown eyes.

She was last seen at her lab wearing a knee-length brown skirt, a bright green T-shirt, brown shoes and a brown necklace.

Debbie Apuzzo, an accountant in the Department of Pharmacology, said 24-year-old Le was "very excited" about getting married. She described Le as energetic and conscientious. The wedding was scheduled for Sunday on Long Island.

Le's fiancé, family, friends, professors and colleagues are all assisting in the investigation. The state police have searched the area with bloodhounds where she was last seen. Law enforcement officers, including members of the FBI, searched the area surrounding the lab as well as Le's Lawrence Street apartment, and security officials are reviewing images from CCTV cameras in the area.

Le received her undergraduate degree from the University of Rochester in New York and majored in cell and developmental biology with a minor in medical anthropology. She conducted a summer project at the National Institutes of Health on bone tissue engineering using mouse mesenchymal stem cells, according to a biography posted on the NIH Web site. While at the University of Rochester, she conducted research involving parasitic wasps.

She is originally from California, and graduated from Union Mine High School in 2003, where she was named "Best of the Best," and "Most Likely To Be The Next Einstein."

Her high school principal, Tony DeVille, described her as being well liked.

"She was very smart, well-rounded, liked by peers and very involved in school," DeVille said.

Anyone with information regarding Le's whereabouts is urged to contact Yale police by dialing 203-432-4400.