All the northbound lanes on Interstate 95 in Guilford were shut down for hours after a crash Thursday afternoon.
The crash, which involved an overturned tractor-trailer, was reported between exits 58 and 59 around 12:45 p.m.
Traffic is also backed up on Route 1 in Guilford.
Drivers were advised to avoid the area and seek alternate routes, police said.
I-95 fully reopened around 4:30 p.m.
It is unclear if anyone was seriously injured in the crash.
State police continue to investigate the cause of the crash.
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