Police said the couple was going through a divorce but still lived together with their four children, ages 14 to 20 years old.
Officials also said an argument on Sunday had turned deadly.
According to police, Thomas Infante allegedly shot his wife after their fight. Then he fled, prompting a police search.
He eventually turned himself in to them.
"He just drove himself here,” said Det. Richard Bango, Shelton police. “After the crime, he drove around and decided to turn himself in. [He] really didn't have a reason."
While the loss of Lisa Infante was felt across the town of Shelton, for her colleagues at Echo House Ambulance, her death was devastating. The mother of four children was a volunteer EMT there for more than 10 years.
"She was just fun to be around,” said Chief Michael Chaffee, Echo House Ambulance. “[She] put you at ease, had a great spirit to her. She was very caring and loving."
On Tuesday, Infante looked down as he appeared before a judge, as his attorney argued he isn't a flight risk since he turned himself in to police.
"I thought that under all the circumstances, his roots to the community, his lack of record, a lower bond was appropriate. The court disagreed to a certain extent," said Attorney John Gulash.
The prosecutor countered that after allegedly killing his wife on Sunday night, Infante hopped into an SUV and took off. He said Infante was allegedly in Pennsylvania, nearing the Ohio border when he turned around.
The CT Coalition Against Domestic Violence said Lisa Infante's death was the fourth intimate partner murder this year.
"This unnecessary death highlights the need for everyone to have increased vigilance about the signs of abusive relationships and knowing where to find help," Karen Jarmoc, president and CEO of CT Coalition Against Domestic Violence said in a statement on Tuesday.
Jarmoc said her organization is worried about the couple's children. Police said the couple had three sons and a daughter.
"We are particularly concerned that two of the couple's children were present at the time of the homicide. Children, no matter how old, are vulnerable to significant trauma when they witness one parent kill another. How the system responds to them following this tragedy will be critical to their ability to cope with the loss," Jarmoc said.
After being transported to the Derby Superior Court, Thomas Infante was arraigned around 2 p.m. His case was continued until Oct. 8 and the judge placed protective orders for two of his children.
For more information about the CT Coalition against Domestic Violence, click here.