Emergency officials responded to a serious crash on Route 12 in Ledyard on Thursday evening.
At about 6 p.m. on Thursday, police said Route 12, between Route 214 and North Glenwoods Road, was closed because of the crash.
Police said the road had reopened at about 9 p.m.
Fire officials said LIFESTAR responded to the area.
Drivers were also being asked to avoid the area.
It is unclear how serious any injuries were, or how the crash happened.
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