Complaints about drug trafficking and an increase in heroin-related overdose deaths led to an operation that netted more than 700 bags of heroin.
Hartford police said they arrested 26-year-old Wilbert Ruperto and 25-year-old Braulino Maysonet after the operation.
Detectives said the surveillance operation on Wednesday focused on the city's south end.
The investigation led to a search and seizure warrant at an apartment on John St.
They said they seized two semi-automatic pistols, ammunition, 746 bags of heroin, 101 grams of powdered heroin, 56 grams of cocaine, more than $16,000, digital scales and packaging materials.
Ruperto was charged with possession of narcotics, possession with intent to sell, operating a drug factory, criminal possession of a pistol, altering the ID of a firearm, reckless driving, evading responsibility, attempted assault on police, interfering with police and not having a license.
Maysonet was charged with possession of narcotics, possession with intent to sell, operating a drug factory and altering a firearm ID.
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